Pooled Protein Immunization for Identification of Cell Surface Antigens in Streptococcus sanguinis

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Pooled Protein Immunization for Identification of Cell Surface Antigens in Streptococcus sanguinis

BACKGROUND Available bacterial genomes provide opportunities for screening vaccines by reverse vaccinology. Efficient identification of surface antigens is required to reduce time and animal cost in this technology. We developed an approach to identify surface antigens rapidly in Streptococcus sanguinis, a common infective endocarditis causative species. METHODS AND FINDINGS We applied bioinf...

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Identification and analysis of potential targets in Streptococcus sanguinis using computer aided protein data analysis

PURPOSE Streptococcus sanguinis is a Gram-positive, facultative aerobic bacterium that is a member of the viridans streptococcus group. It is found in human mouths in dental plaque, which accounts for both dental cavities and bacterial endocarditis, and which entails a mortality rate of 25%. Although a range of remedial mediators have been found to control this organism, the effectiveness of ag...

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ژورنال

عنوان ژورنال: PLoS ONE

سال: 2010

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0011666